MovDisordV3, Main, Exploration, bibRecord, 001069

Locus Coeruleus Neuron Density and Parkinsonism in Older Adults Without Parkinson's Disease

Identifieur interne : 001069 ( Main/Exploration ); précédent : 001068; suivant : 001070

Locus Coeruleus Neuron Density and Parkinsonism in Older Adults Without Parkinson's Disease

Auteurs : Aron S. Buchman [États-Unis] ; Sukriti Nag [États-Unis] ; Joshua M. Shulman [États-Unis] ; Andrew S. P. Lim [Canada] ; Veronique G. J. M. Vanderhorst [États-Unis] ; Sue E. Leurgans [États-Unis] ; Julie A. Schneider [États-Unis] ; David A. Bennett [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:13-0017925

Descripteurs français

Pascal (Inist)
- Parkinsonisme, Maladie de Parkinson, Pathologie du système nerveux, Locus coeruleus, Neurone, Locus niger.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Aging (pathology), Amyloid (metabolism), Cell Count, Female, Humans, Lewy Bodies (pathology), Locus Coeruleus (pathology), Locus coeruleus, Locus niger, Male, Nervous system diseases, Neuron, Neurons (pathology), Neurons (ultrastructure), Parkinson disease, Parkinsonian Disorders (pathology), Parkinsonism, Postmortem Changes, Psychiatric Status Rating Scales.
MESH :
- chemical , metabolism : Amyloid.
- pathology : Aging, Lewy Bodies, Locus Coeruleus, Neurons, Parkinsonian Disorders.
- ultrastructure : Neurons.
- Aged, Aged, 80 and over, Cell Count, Female, Humans, Male, Postmortem Changes, Psychiatric Status Rating Scales.

Abstract

Previous work has showed that nigral neuron density is related to the severity of parkinsonism proximate to death in older persons without a clinical diagnosis of Parkinson's disease (PD). We tested the hypothesis that neuron density in other brain stem aminergic nuclei is also related to the severity of parkinsonism. We studied brain autopsies from 125 deceased older adults without PD enrolled in the Memory and Aging Project, a clinicopathologic investigation. Parkinsonism was assessed with a modified version of the Unified Parkinson's Disease Rating Scale (UPDRS). We measured neuron density in the substantia nigra, ventral tegmental area, locus coeruleus, and dorsal raphe, along with postmortem indices of Lewy body disease, Alzheimer's disease and cerebrovascular pathologies. Mean age at death was 88.0 years, and global parkinsonism was 14.8 (SD, 9.50). In a series of regression models that controlled for demographics and neuron density in the substantia nigra, neuron density in the locus coeruleus (estimate, -0.261; SE, 0.117; P = .028) but not in the ventral tegmental area or dorsal raphe was associated with severity of global parkinsonism proximate to death. These findings were unchanged in models that controlled for postmortem interval, whole-brain weight, and other common neuropathologies including Alzheimer's disease and Lewy body pathology and cerebrovascular vascular pathologies. In older adults without a clinical diagnosis of PD, neuron density in locus coeruleus nuclei is associated with the severity of parkinsonism and may contribute to late-life motor impairments.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628555

Affiliations:

Le document en format XML

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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Aging (pathology)</term>
<term>Amyloid (metabolism)</term>
<term>Cell Count</term>
<term>Female</term>
<term>Humans</term>
<term>Lewy Bodies (pathology)</term>
<term>Locus Coeruleus (pathology)</term>
<term>Locus coeruleus</term>
<term>Locus niger</term>
<term>Male</term>
<term>Nervous system diseases</term>
<term>Neuron</term>
<term>Neurons (pathology)</term>
<term>Neurons (ultrastructure)</term>
<term>Parkinson disease</term>
<term>Parkinsonian Disorders (pathology)</term>
<term>Parkinsonism</term>
<term>Postmortem Changes</term>
<term>Psychiatric Status Rating Scales</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amyloid</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aging</term>
<term>Lewy Bodies</term>
<term>Locus Coeruleus</term>
<term>Neurons</term>
<term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Neurons</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cell Count</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Postmortem Changes</term>
<term>Psychiatric Status Rating Scales</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinsonisme</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Locus coeruleus</term>
<term>Neurone</term>
<term>Locus niger</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Previous work has showed that nigral neuron density is related to the severity of parkinsonism proximate to death in older persons without a clinical diagnosis of Parkinson's disease (PD). We tested the hypothesis that neuron density in other brain stem aminergic nuclei is also related to the severity of parkinsonism. We studied brain autopsies from 125 deceased older adults without PD enrolled in the Memory and Aging Project, a clinicopathologic investigation. Parkinsonism was assessed with a modified version of the Unified Parkinson's Disease Rating Scale (UPDRS). We measured neuron density in the substantia nigra, ventral tegmental area, locus coeruleus, and dorsal raphe, along with postmortem indices of Lewy body disease, Alzheimer's disease and cerebrovascular pathologies. Mean age at death was 88.0 years, and global parkinsonism was 14.8 (SD, 9.50). In a series of regression models that controlled for demographics and neuron density in the substantia nigra, neuron density in the locus coeruleus (estimate, -0.261; SE, 0.117; P = .028) but not in the ventral tegmental area or dorsal raphe was associated with severity of global parkinsonism proximate to death. These findings were unchanged in models that controlled for postmortem interval, whole-brain weight, and other common neuropathologies including Alzheimer's disease and Lewy body pathology and cerebrovascular vascular pathologies. In older adults without a clinical diagnosis of PD, neuron density in locus coeruleus nuclei is associated with the severity of parkinsonism and may contribute to late-life motor impairments.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Illinois</li>
<li>Massachusetts</li>
<li>Ontario</li>
</region>
<settlement><li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Illinois"><name sortKey="Buchman, Aron S" sort="Buchman, Aron S" uniqKey="Buchman A" first="Aron S." last="Buchman">Aron S. Buchman</name>
</region>
<name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<name sortKey="Buchman, Aron S" sort="Buchman, Aron S" uniqKey="Buchman A" first="Aron S." last="Buchman">Aron S. Buchman</name>
<name sortKey="Leurgans, Sue E" sort="Leurgans, Sue E" uniqKey="Leurgans S" first="Sue E." last="Leurgans">Sue E. Leurgans</name>
<name sortKey="Leurgans, Sue E" sort="Leurgans, Sue E" uniqKey="Leurgans S" first="Sue E." last="Leurgans">Sue E. Leurgans</name>
<name sortKey="Nag, Sukriti" sort="Nag, Sukriti" uniqKey="Nag S" first="Sukriti" last="Nag">Sukriti Nag</name>
<name sortKey="Nag, Sukriti" sort="Nag, Sukriti" uniqKey="Nag S" first="Sukriti" last="Nag">Sukriti Nag</name>
<name sortKey="Schneider, Julie A" sort="Schneider, Julie A" uniqKey="Schneider J" first="Julie A." last="Schneider">Julie A. Schneider</name>
<name sortKey="Schneider, Julie A" sort="Schneider, Julie A" uniqKey="Schneider J" first="Julie A." last="Schneider">Julie A. Schneider</name>
<name sortKey="Schneider, Julie A" sort="Schneider, Julie A" uniqKey="Schneider J" first="Julie A." last="Schneider">Julie A. Schneider</name>
<name sortKey="Shulman, Joshua M" sort="Shulman, Joshua M" uniqKey="Shulman J" first="Joshua M." last="Shulman">Joshua M. Shulman</name>
<name sortKey="Shulman, Joshua M" sort="Shulman, Joshua M" uniqKey="Shulman J" first="Joshua M." last="Shulman">Joshua M. Shulman</name>
<name sortKey="Vanderhorst, Veronique G J M" sort="Vanderhorst, Veronique G J M" uniqKey="Vanderhorst V" first="Veronique G. J. M." last="Vanderhorst">Veronique G. J. M. Vanderhorst</name>
<name sortKey="Vanderhorst, Veronique G J M" sort="Vanderhorst, Veronique G J M" uniqKey="Vanderhorst V" first="Veronique G. J. M." last="Vanderhorst">Veronique G. J. M. Vanderhorst</name>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Lim, Andrew S P" sort="Lim, Andrew S P" uniqKey="Lim A" first="Andrew S. P." last="Lim">Andrew S. P. Lim</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Movement Disorders (revue)

Locus Coeruleus Neuron Density and Parkinsonism in Older Adults Without Parkinson's Disease

Locus Coeruleus Neuron Density and Parkinsonism in Older Adults Without Parkinson's Disease

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